Energetic dependencies dictate folding mechanism in a complex protein
نویسندگان
چکیده
منابع مشابه
Structural and Energetic Heterogeneity in Protein Folding
A general theoretical framework is developed using free energy functional methods to understand the effects of heterogeneity in the folding of a well-designed protein. Native energetic heterogeneity arising from non-uniformity in native stability, as well as entropic heterogeneity intrinsic to the topology of the native structure are both investigated as to their impact on the folding free ener...
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A new lattice protein model with a four-helix bundle ground state is analyzed by a parameter-space Monte Carlo histogram technique to evaluate the effects of an extensive variety of model potentials on folding thermodynamics. Cooperative helical formation and contact energies based on a 5-letter alphabet are found to be insufficient to satisfy calorimetric and other experimental criteria for tw...
متن کاملStructural and energetic heterogeneity in protein folding. I. Theory
A general theoretical framework is developed using free-energy functional methods to understand the effects of heterogeneity in the folding of a well-designed protein. Native energetic heterogeneity arising from nonuniformity in native stabilizing interactions, as well as entropic heterogeneity intrinsic to the topology of the native structure, are both investigated as to their impact on the fo...
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polypeptides and rebinding of nonnative species in the central cavity of GroEL (reviewed by Fenton and HorFolding of proteins in a test tube is a private affair. wich, 1997). Protein folding in a cell is another matter entirely. In the For a number of years the predominant model for an complex milieu of the cell, the conditionsof temperature, in vivo protein folding pathway has been the sequent...
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In a previous study, a surprising drying transition was observed to take place inside the nanoscale hydrophobic channel in the tetramer of the protein melittin. The goal of this paper is to determine if there are other protein complexes capable of displaying a dewetting transition during their final stage of folding. We searched the entire protein data bank (PDB) for all possible candidates, in...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2019
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1914366116